VEGF-A Biotinylated, bovine recombinant (rboVEGF-A)

Produced in Yeast. Amino acid sequence: APMAEGGQKP HEVVKFMDVY QRSFCRPIET LVDIFQEYPD EIEFIFKPSC VPLMRCGGCC NDESLECVPT EEFNITMQIM RIKPHQSQHI GEMSFLQHNK CECRPKKDKA RQENPCGPCS ERRKHLFVQD PQTCKCSCKN TDSRCKARQL ELNERTCRCD. Protein function: Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development. [The UniProt Consortium]