Human GITR Ligand Protein, mFc-His tag

Recombinant human GITR Ligand protein with N-terminal mouse Fc and C-terminal 6×His tag. mFc(Pro99-Lys330) GITR Ligand(Gln50-Ser177) 6×His, Protein function: Cytokine that binds to TNFRSF18/AITR/GITR (PubMed:14521928, PubMed:14647196). Regulates T-cell responses (PubMed:14647196). Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation (PubMed:14608036, PubMed:15128759). Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B (PubMed:14521928, PubMed:14647196, PubMed:18178614). Triggers increased phosphorylation of STAT1 and up- regulates expression of VCAM1 and ICAM1. Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (PubMed:24107315). [The UniProt Consortium]