GITR Ligand/TNFSF18 Protein (Fc Tag) (recombinant mouse)

Sequence: Thr47-Ser173. Fusion tag: C-Fc Endotoxin: < 1.0 EU per µg of the protein as determined by the LAL method Observed Molecular Mass: 40 kDa. Protein function: Protein function: Cytokine that binds to TNFRSF18/AITR/GITR (PubMed:14521928, PubMed:14647196). Regulates T-cell responses (PubMed:14647196). Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation (PubMed:14608036, PubMed:15128759). Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B (PubMed:14521928, PubMed:14647196, PubMed:18178614). Triggers increased phosphorylation of STAT1 and up- regulates expression of VCAM1 and ICAM1. Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (PubMed:24107315). [The UniProt Consortium]