CGRP Protein (mouse), hFc Tag

Description: Recombinant mouse CGRP protein with C-terminal human Fc tag Background: This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide (CGRP) and katacalcin. Alternative splicing of the mRNA results in multiple variants that encode either calcitonin or CGRP preproproteins. Post-translational processing of the calcitonin and CGRP propeptides results in either calcitonin and katacalcin, or CGRP, respectively. Calcitonin and katacalcin modulate calcium levels in the blood stream. CGRP can function as a vasodilator and play a role in the transmission of pain. The human homolog of CGRP was found to have antimicrobial activity. Molecular Characterization: mass of 29.9 kDa after removal of the signal peptide. The apparent molecular mass of mCGRP-hFc is approximately 25-35 kDa due to glycosylation. Tag: C-Human Fc Tag Protein function: CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP. [The UniProt Consortium]