SUMO2 protein-HIS Epitope

SUMO2 protein-HIS Epitope
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
009-001-T67 50 µg - -

6 - 10 Werktage*

402,00 €
 
Recombinant human SUMO2 (1-93) was expressed in E. coli cells using an N-Terminal his epitope.... mehr
Produktinformationen "SUMO2 protein-HIS Epitope"
Recombinant human SUMO2 (1-93) was expressed in E. coli cells using an N-Terminal his epitope. The purity was determined to be >95% by densitometry. Protein function: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (PubMed:18408734, PubMed:18538659, PubMed:21965678, PubMed:9556629). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744). [The UniProt Consortium]
Schlagworte: Smt3B, HSMT3, SUMO-2, SUMO-3, Sentrin-2, SMT3 homolog 2, Ubiquitin-like protein SMT3B, Small ubiquitin-related modifier 2
Hersteller: Rockland Immunochemicals
Hersteller-Nr: 009-001-T67

Eigenschaften

Anwendung: WB
Konjugat: No
Wirt: Human

Handhabung & Sicherheit

Lagerung: -80°C
Versand: -20°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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