STING R232 variant (human, recombinant)

Stimulator of interferon genes (STING) is a component of the innate immune response that binds to cyclic dinucleotides, which are bacterial second messengers, leading to activation of NF-kappaB and transcription of immunomodulatory genes, including type I interferon (IFN). The R232 variant is the most common variant in the human population, found at a frequency of 57.9% in the 1000 Genome Project. The SNP variant H232 (Cay-22815) is found at a 13.7% frequency. Various mutations in STING either reduce or increase its activity. Gain-of-function mutations in STING, including R284M (Cay-23594) and V155M, lead to constitutive activation and enhancement of the type I IFN response. The V155M mutation is associated with a systemic inflammatory condition, including pulmonary fibrosis and autoimmune factors. Mutations that reduce STING activity include K224R (Cay-23593), which reduces ubiquitination of STING thereby disrupting its localization within the cell, and the double mutation G230A, R293Q (Cay-23592), which reduces the IFN response. A T596A mutation present in the mouse strain Goldenticket leads to a complete loss of STING protein and lack of a type I IFN response to infection by Listeria.Synonyms: Endoplasmic Reticulum Interferon Stimulator, ERIS, hSTING, MITA, MPYS, Stimulator of Interferon Genes, TMEM173. Purity: >80% estimated by SDS-PAGE. Source: Recombinant N-terminal His-tagged STING catalytic domain purified from E. coli. Amino Acids: 138-379 (N-terminal truncation), R232 variant. Formulation: (Request formulation change), 50 mM HEPES, pH 8.0, 150 mM sodium chloride, 10% glycerol. UniProt Accession #: Q86WV6.