SIRP alpha V4 Protein, Human, Recombinant (His & Avi)

Description: Signal regulatory protein alpha (SIRPalpha) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPalpha acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don ´t eat me" signal.Cancer cells highly expressed CD47 that activate SIRP alpha and inhibit macrophage-mediated destruction. SIRP alpha V4 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 39.8 kDa and the accession number is P78324 variant 4.