SARS-CoV Nucleocapsid Protein, His-SUMOtag, HEK293

Sequence: MSDNGPQSNQ RSAPRITFGG PTDSTDNNQN GGRNGARPKQ RRPQGLPNNT ASWFTALTQH GKEELRFPRG QGVPINTNSG RRATRRVRGG DGKMKELSPR WYFYYLGTGP EASLPYGANE GIVWVATEGA LNTPKDHIGT RNPNNNAATV LQLPQGTTLP GSQASSRSSS RSRGNSRNST PGSSRGNSPA RMASGGGETA LALLLLDRLN QLESKVSGKG QQQQGQTVTK KSAAEAKKPR VTQAFGRRGP EQTQGNFGDQ DLIRQGTDYK HWPQIAQFAP SASAFFGMSR IGMEVTPSGT WLTYHGAIKL DDKDPQFKDN YKTFPPTEPK KDKKKKTDEA QPLQRQKKQP TVTLLPAADM DDFSRQLQNS MSGASADSTQ with polyhistidine-SUMO tag at the N-terminus. Endotoxin level: <0.1 EU per 1 µg of the protein by the LAL method. Protein function: Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication (PubMed:17210170). May modulate transforming growth factor-beta signaling by binding host SMAD3 (PubMed:18055455). [The UniProt Consortium]