Recombinant Human Cytotoxic T-lymphocyte Protein 4 (C-GST)

Recombinant Human Cytotoxic T-lymphocyte Protein 4 (C-GST)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ABE-32-8844-10 10 µg - -

3 - 11 Werktage*

426,00 €
ABE-32-8844-50 50 µg - -

3 - 11 Werktage*

546,00 €
 
Source: Human Cells. MW :39.2kD. Recombinant Human Cytotoxic T-lymphocyte Protein 4 is produced... mehr
Produktinformationen "Recombinant Human Cytotoxic T-lymphocyte Protein 4 (C-GST)"
Source: Human Cells. MW :39.2kD. Recombinant Human Cytotoxic T-lymphocyte Protein 4 is produced by our Mammalian expression system and the target gene encoding Lys36-Asp161 is expressed with a GST tag at the C-terminus. Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule that is a member of the Ig superfamily. Human or mouse CTLA4 cDNA encodes 223 amino acids (aa) including a 35 aa signal sequence, a 126 aa extracellular domain (ECD) with one Ig-like V-type domain, a 21 aa transmembrane (TM) sequence, and a 41 aa cytoplasmic sequence.It is widely expressed with highest levels in lymphoid tissues. CD28 and CTLA-4, together with their ligands, B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD28 and CTLA-4 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T Cells and may play an important role in their functions. Tcell activation through the Tcell receptor and CD28 leads to increased expression of CTLA4. Protein function: Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. [The UniProt Consortium]
Hersteller: Abeomics
Hersteller-Nr: 32-8844

Eigenschaften

Konjugat: No

Handhabung & Sicherheit

Lagerung: +20°C
Versand: +20°C (International: +20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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