Recombinant Human CD19 (C-Fc)

Recombinant Human CD19 (C-Fc)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ABE-32-7516-10 10 µg - -

3 - 11 Werktage*

478,00 €
ABE-32-7516-50 50 µg - -

3 - 11 Werktage*

791,00 €
 
Source: Human Cells. MW :57.3kD. Recombinant Human CD19 is produced by our Mammalian expression... mehr
Produktinformationen "Recombinant Human CD19 (C-Fc)"
Source: Human Cells. MW :57.3kD. Recombinant Human CD19 is produced by our Mammalian expression system and the target gene encoding Pro20-Lys291 is expressed with a Fc tag at the C-terminus. CD19 is a single-pass type I membrane protein containing 2 Ig-like C2-type (immunoglobulin-like) domains. CD19 is expressed on follicular dendritic cells and B cells. In fact, it is present on B cells from earliest recognizable B-lineage cells during development to B-cell blasts but is lost on maturation to plasma cells. CD19 primarily acts as a B cell co-receptor in conjunction with CD21 and CD81. Upon activation, the cytoplasmic tail of CD19 becomes phosphorylated, which leads to binding by Src-family kinases and recruitment of PI-3 kinase. CD19 Assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. Defects in CD19 are the cause of immunodeficiency common variable type 3 (CVID3) which is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. Protein function: Assembles with the antigen receptor of B-lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. [The UniProt Consortium]
Hersteller: Abeomics
Hersteller-Nr: 32-7516

Eigenschaften

Konjugat: No

Handhabung & Sicherheit

Lagerung: +20°C
Versand: +20°C (International: +20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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