Recombinant Human 3-Hydroxybutyrate Dehydrogenase Type 2/BDH2/DHRS6 (N-6His)

Source: E.coli. MW :28.9kD. Recombinant Human DHRS6 is produced by our E.coli expression system and the target gene encoding Met1-Leu245 is expressed with a 6His tag at the N-terminus. 3-Hydroxybutyrate Dehydrogenase Type 2 belongs to the short-chain dehydrogenases/reductases (SDR) family. 3-Hydroxybutyrate Dehydrogenase Type 2 may play an important role in the peripheral utilization of 3-hydroxybutyrate. The cytoplasmic localization with its high ratio of oxidized NAD+, the NAD+ dependence and the kinetic parameters of 3-Hydroxybutyrate Dehydrogenase Type 2 make it suitable to conbert high levels of circulating 3-hydroxybutyrate into acetoacetate. Protein function: Dehydrogenase that mediates the formation of 2,5- dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron homeostasis and transport. Also acts as a 3-hydroxybutyrate dehydrogenase. [The UniProt Consortium]