PRMT6 (human recombinant, baculovirus expressed)

Protein arginine methyltransferases (PRMTs) are a family of enzymes with highly conserved catalytic domains that catalyze the transfer of a methyl group from S-adenosyl-L-methionine to a specific arginine residue in a target protein. PRMT6 is a nuclear type-1 PRMT, catalyzing the formation of omega-NG-monomethylarginine and asymmetric omega-NG,NG-dimethylarginine on both histone and non-histone targets. Histone H3 methylation of arginine 2 (H3R2) is a repressive transcriptional mark primarily catalyzed by PRMT6. H3R2 dimethylation antagonizes the binding of effector proteins sensitive to H3K4 methylation, such as the Mixed Lineage Leukemia complex methyltransferase. Non-histone targets of PRMT6 include the nuclear high-mobility group protein HMGA1a, a protein important in several processes relating to the maintenance of DNA integrity.Synonyms: Histone Arginine N-methyltransferase PRMT6, HRMT1L6, Protein Arginine Methyltransferase 6. Purity: >60%. Source: Recombinant N-terminal His-tagged protein expressed in Sf21 cells. Amino Acids: 2-375 (full length). MW: 43.7 kDa. Formulation: (Request formulation change), 50 mM Tris-HCl, pH 8.0, with 150 mM sodium chloride and 20% glycerol. UniProt Accession #: Q96LA8.