PPAR-alpha protein (His tag), recombinant rat

Activity: Testing in progress Protein Construction: A DNA sequence encoding the Rat PPAR-alpha protein (P37230) (Ser 280-Leu 433) was expressed with a N-His tag. Sequence: Ser 280-Leu 433. Fusion tag: N-His Endotoxin: Please contact us for more information. Apparent Molecular Mass: 18 kDa. Protein function: Peroxisome Proliferator-Activated Receptor alpha (PPAR alpha , NR1C1) is a member of the Nuclear Receptor superfamily. PPAR alpha exhibits the highest affinity with unsaturated fatty acids, and linolenic acids. PPAR alpha is expressed in brown fat, liver, Protein function: Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn- glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2. [The UniProt Consortium]