OX40 (human):Fc (human, rec.)

(3 x 50µg). Human OX40 (amino acids 29-214) is fused at the C-terminus to the Fc portion of human IgG1. Blocks T cell proliferation induced by CD134L. Lyophilized. Contains PBS. OX40 binds to receptors on T-cells, preventing them from dying and subsequently increasing cytokine production. OX40 has a critical role in the maintenance of an immune response. OX40:Fc was shown to prevent OX40 from reaching the T-cell receptors, thus reducing the T-cell response. Experiments in mice have demonstrated that OX40:Fc can reduce the symptoms associated with the cytokine storm (an immune overreaction) while allowing the immune system to fight off the virus successfully.