Non-receptor tyrosine-protein kinase TYK2 (TYK2), partial, human, recombinant

Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 556-871aa. Protein Length: Partial. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: GETSNLIIMR GARASPRTLN LSQLSFHRVD QKEITQLSHL GQGTRTNVYE GRLRVEGSGD PEEGKMDDED PLVPGRDRGQ ELRVVLKVLD PSHHDIALAF YETASLMSQV SHTHLAFVHG VCVRGPENIM VTEYVEHGPL DVWLRRERGH VPMAWKMVVA QQLASALSYL ENKNLVHGNV CGRNILLARL GLAEGTSPFI KLSDPGVGLG ALSREERVER IPWLAPECLP GGANSLSTAM DKWGFGATLL EICFDGEAPL QSRSPSEKEH FYQRQHRLPE PSCPQLATLT SQCLTYEPTQ RPSFRTILRD LTRLQP. Purity: Greater than 85% as determined by SDS-PAGE. Endotoxin: Not test. Biological Activity: n/a. Form: Liquid or Lyophilized powder. Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0. Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20 °C/-80 °C. Our default final concentration of glycerol is 50%. Customers could use it as reference. Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 °C/-80 °C. The shelf life of lyophilized form is 12 months at -20 °C/-80 °C. Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 °C for up to one week. Relevance: Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain. Reference: "Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase." Colamonici O., Yan H., Domanski P., Handa R., Smalley D., Mullersman J., Witte M., Krishnan K., Krolewski J. Mol. Cell. Biol. 14:8133-8142(1994). Function: nan