Nampt (mouse) (rec.) (enzymatically active)

Nampt (mouse) (rec.) (enzymatically active)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
AG-40B-0179-C050 50 µg -

3 - 9 Werktage*

429,00 €
 
Protein function: The secreted form behaves both as a cytokine with immunomodulating properties... mehr
Produktinformationen "Nampt (mouse) (rec.) (enzymatically active)"
Protein function: The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD- dependent SIRT1-mediated suppression. [The UniProt Consortium]
Schlagworte: PBEF, Nampt, Pbef1, Visfatin, NAmPRTase, EC=2.4.2.12, Nicotinamide phosphoribosyltransferase, Pre-B-cell colony-enhancing factor 1 homolog
Hersteller: AdipoGen Life Sciences
Hersteller-Nr: AG-40B-0179

Eigenschaften

Konjugat: No

Handhabung & Sicherheit

Lagerung: -80°C
Versand: -20°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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