Mouse PD-L2/B7-DC Protein

Recombinant Mouse PD-L2/B7-DC Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Leu20-Trp221. PD-1 ligand 2 (PD-L2) as a second ligand for PD-1 and compare the function and expression of PD-L1 and PD-L2. Engagement of PD-1 by PD-L2 dramatically inhibits T cell receptor (TCR)-mediated proliferation and cytokine production by CD4 T cells. At low antigen concentrations, PD-L2-PD-1 interactions inhibit strong B7-CD28 signals.