Mouse PD-L1 Protein, hFc Tag

Recombinant mouse PD-L1 protein with C-terminal human Fc tag. Mouse PD-L1(Phe19-Arg237) hFc(Glu99-Ala330), Protein function: Plays a critical role in induction and maintenance of immune tolerance to self (PubMed:11238124). As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed:11238124). Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (PubMed:11015443, PubMed:12719480). [The UniProt Consortium]