Lck, p56lck, active, Recombinant, Human (Lymphocyte-specific Tyrosine Kinase)

LCK (p56lck) is a member of the Src family of non-receptor tyrosine kinases. It was identified as a gene rearranged and over-expressed in the murine lymphoma LSTRA, most likely as a result of the insertion of Moloney murine leukemia virus DNA immediately adjacent to the gene (1). LCK behaves as a proto-oncogene and can lead to cell transformation upon activation. A number of human cancer cell lines show over-expression of LCK, pointing to a possible role for this kinase in the initiation and maintenance of the transformed state in human cancers (2). Source: Recombinant full-length human LCK was expressed by baculovirus in Sf 9 insect cells using an N-terminal GST tag. The gene accession number is NM_005356. , Molecular Mass: The approximate molecular weight is 84 kD. Activity: The specific activity of LCK was determined to be 239 nmol/min/mg using a Poly (Glu:Tyr, 4:1) synthetic peptide substrate (see activity assay protocol). , Storage: This product is stable at < -70° C for at least 6 months from the date of receipt. For optimal storage, aliquot into smaller quantities after centrifugation and store at recommended temperature. Avoid repeated freeze-thaw cycles.