JAK2 JH2 Domain (human, recombinant, aa 513-827) - Biotinylated

JAK2 is a non-receptor tyrosine kinase that has roles in immune signaling. It is composed of N-terminal FERM and SH2 domains, a regulatory JH2 pseudokinase domain, and a C-terminal JH1 kinase domain. It is widely expressed and associates with class I and class II cytokine receptors at the plasma membrane. Activation of these cytokine receptors activates JAK2 and induces its dimerization and kinase activity, leading to JAK2 phosphorylation of STAT transcription factors and transcription of immune-related target genes. JAK2 signaling is inhibited by the suppressor of cytokine signaling (SOCS) proteins SOCS1 and SOCS3. Gain-of-function mutations in JAK2, such as JAK2V617F in the JH2 domain, are associated with various blood disorders, including leukemias and myeloproliferative neoplasms. Cayman's JAK2 JH2 Domain (human, recombinant, aa 513-827) - Biotinylated protein can be used for pull-down assays and has a calculated molecular weight of 39 kDa.Synonyms: Janus-Associated Kinase 2, JTK10, Tyrosine-Protein Kinase JAK2. Purity: >90% estimated by SDS-PAGE. Source: Recombinant human C-terminal His-tagged biotinylated JAK2 JH2 domain expressed in insect cells (Sf9). Amino Acids: 513-827. MW: 39 kDa. Formulation: (Request formulation change), 40 mM Tris-HCl, pH 8.0, 300 mM sodium chloride, 2.2 mM potassium chloride, 20% glycerol, and 0.2 mM TCEP. UniProt Accession No: O60674.