Jagged-1 (human):Fc (human, rec.)

Signal peptide and extracellular domain of human Jagged-1 (HJ1, CD339) (amino acids 1-1067) are fused at the C-terminus to the Fc portion of human IgG1. Inhibits adipogenesis of mesenchymal stem cells (MSCs). Induces Hes-1 in 3T3L-1 cells. Liquid. 0.2µm-filtered solution in PBS. Jagged-1 is a ligand for multiple Notch receptors and involved in the mediation of Notch signaling. It is involved in cell-fate decisions during hematopoiesis. Is involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. Enhances fibroblast growth factor-induced angiogenesis (in vitro). Defects in Jagged-1 are the cause of Alagille syndrome type 1 (ALGS1) and tetralogy of Fallot (TOF).