Human VEGF110 Protein

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
KT-VEG-HM010-100UG 100 µg -

7 - 10 Werktage*

337,00 €
KT-VEG-HM010-500UG 500 µg -

7 - 10 Werktage*

1.122,00 €
 
Recombinant Human VEGF110 Protein is expressed from HEK293 without tag.It contains Ala27-Arg136.... mehr
Produktinformationen "Human VEGF110 Protein"
Recombinant Human VEGF110 Protein is expressed from HEK293 without tag.It contains Ala27-Arg136. Vascular endothelial growth factor-A (VEGF-A) is a critical angiogenic factor which is mainly secreted from podocytes and epithelial cells in kidney and plays an important role in renal pathophysiology. In recent years, functions of different isoforms of VEGF-A and the new secretion approach via extracellular vesicles (EVs) have been identified. Protein function: Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development. Also binds the DEAR/FBXW7-AS1 receptor (PubMed:17446437). [The UniProt Consortium]
Schlagworte: VPF, VEGF, VEGFA, VEGF-A, Vascular permeability factor, Vascular endothelial growth factor A
Hersteller: KACTUS
Hersteller-Nr: VEG-HM010

Eigenschaften

Konjugat: No
Wirt: Human cells
Spezies-Reaktivität: human
MW: 12.70 kD
Reinheit: >95% (Bis-Tris PAGE),>95% (HPLC)
Format: Solution

Handhabung & Sicherheit

Lagerung: +4°C
Versand: -20°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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