Human TNFRSF10B Protein, mFc Tag

Recombinant human TNFRSF10B protein with C-terminal mouse Fc tag. TNFRSF10B (Ile56-Glu182) mFc(Pro99-Lys330), Protein function: Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:10549288). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis. [The UniProt Consortium]