Human TLR3 Protein, mFc Tag

Recombinant human TLR3 protein with C-terminal mouse Fc tag. TLR3(Ser24-Leu704) mFc(Pro99-Lys330), Protein function: Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response. [The UniProt Consortium]