Human HER3(544-643) Protein, hFc Tag

Recombinant human HER3(544-643) Protein with C-terminal human Fc tag. HER3(Ala544-Thr643) hFc(Glu99-Ala330), Protein function: Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it, ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134). Involved in the regulation of myeloid cell differentiation (PubMed:27416908). [The UniProt Consortium]