Human GFRAL/GFR alpha-like Protein

Recombinant Human GFRAL/GFR alpha-like Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Ser19-Glu351. GFR alpha -like (GDNF receptor-alpha-like) is a distant member of the GDNFR family of proteins. Mature human GFR alpha-like is a 376 amino acid (aa) type I transmembrane protein. It contains a 333 aa extracellular domain, a 20 aa transmembrane domain and a 23 aa cytoplasmic domain.GFRAL is a brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses.