Human FOLR2 Protein, mFc Tag

Recombinant human FOLR2 protein with C-terminal mouse Fc tag. FOLR2(Thr17-His228) mFc(Pro99-Lys330), Protein function: Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. [The UniProt Consortium]