Human FOLR1 Protein, His Tag

Recombinant Human FOLR1 Protein with C-terminal 6×His tag. FOLR1(Arg25-Ser234) 6×His tag, Protein function: Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. [The UniProt Consortium]