Human CD8 alpha&beta Heterodimer Protein

Recombinant Human CD8 alpha&beta Heterodimer Protein is expressed from HEK293 with His tag and Flag tag at the C-Terminus.It contains Ser22-Asp182(CD8 alpha) acidic tail and Leu22-Pro170(CD8 beta) basic tail. CD8 alpha&beta (CD8alphabeta) is a heterodimeric form of CD8. CD8alpha is required for surface expression of CD8beta. The extracellular IgV-like domain of CD8alpha interacts with the alpha3 portion of the class I MHC molecule. CD8alphabeta is expressed on human peripheral T cells and functions as a coreceptor and can greatly increase the sensitivity and breadth of antigen recognition by CD8⁺ peripheral T cells bearing TCR.