Human CD28 Protein, mFc-His Tag

Recombinant human CD28 protein with C-terminal mouse Fc and 6×His tag. CD28(Asn19-Pro152) mFc(Pro99-Lys330) 6×His, Protein function: Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation (PubMed:8617933). Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells (PubMed:15067037). [The UniProt Consortium]