Human B7-H4 Protein, hFc Tag

Recombinant Human B7-H4 protein with C-terminal human Fc. B7-H4 (Phe29-Ala258) hFc(Glu99-Ala330), Protein function: Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T- cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation. [The UniProt Consortium]