Human ACVR1B/ALK-4 Protein

Recombinant Human ACVR1B/ALK-4 Protein is expressed from HEK293 with His tag at the C-terminus.It contains Ser24-Glu126. Activin A receptor type I (ACVR1) encodes for a bone morphogenetic protein type I receptor of the TGFbeta receptor superfamily. It is involved in a wide variety of biological processes, including bone, heart, cartilage, nervous, and reproductive system development and regulation. Moreover, ACVR1 has been extensively studied for its causal role in fibrodysplasia ossificans progressiva (FOP), a rare genetic disorder characterised by progressive heterotopic ossification. ACVR1 is linked to different pathologies, including cardiac malformations and alterations in the reproductive system.