HDAC6 (human, recombinant)

HDAC6 is a Class II HDAC that can shuttle between the nucleus and cytoplasm, suggesting potential extranuclear functions by regulating the acetylation status of non-histone substrates. By modifying chromatin structure and other non-histone proteins, HDACs play important roles in controlling complex biological events, including cell development, differentiation, programmed cell death, angiogenesis, and inflammation. Considering these major roles, it is conceivable that dysregulation of HDACs and subsequent imbalance of acetylation and deacetylation may be involved in the pathogenesis of various diseases, including cancer and inflammatory diseases.Synonyms: Histone Deacetylase 6. Purity: >65% estimated by SDS-PAGE. Source: 50 µg of full-length recombinant N-terminal GST-tagged protein expressed in Sf9 cells. Amino Acids: 2-1215 (full length). MW: 159 kDa. Formulation: (Request formulation change), 40 mM Tris-HCl, pH 8.0, 110 mM sodium chloride, with 2.2 mM potassium chloride, 0.04% Tween 20, 3 mM DTT, and 20% glycerol. UniProt Accession #: Q9UBN7.