FFAR1 (human) full length protein-synthetic nanodisc

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
DIM-FLP100134.10 10 µg - -

7 - 16 Werktage*

1.291,00 €
DIM-FLP100134.50 50 µg - -

7 - 16 Werktage*

6.311,00 €
DIM-FLP100134.100 100 µg - -

7 - 16 Werktage*

11.474,00 €
 
Discover a breakthrough in membrane protein research and drug development with DIMA Biotech's... mehr
Produktinformationen "FFAR1 (human) full length protein-synthetic nanodisc"
Discover a breakthrough in membrane protein research and drug development with DIMA Biotech's Synthetic Nanodiscs. Traditional methods struggle with challenges in obtaining water-soluble and bioactive forms of multi-transmembrane proteins. Our innovative polymer-based Nanodisc platform offers a game-changing solution by excluding membrane scaffold proteins (MSPs), resulting in a cleaner system with fewer interferences for downstream assays. By disassembling cell membranes into nanoscale disc-shaped structures, our technology enables the purification of membrane proteins to high homogeneity under aqueous conditions. Explore how Synthetic Nanodiscs empower the functional characterization of multi-span transmembrane proteins in their active form, revolutionizing the future of membrane protein research and drug development. Protein function: G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis, receptor signaling activates pathways that inhibit osteoclast differentiation. Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway. Mediates the anti-inflammatory effects of omega-3 polyunsaturated fatty acids (PUFAs) via inhibition of NLRP3 inflammasome activation. [The UniProt Consortium]
Schlagworte: GPR40, FFAR1, Free fatty acid receptor 1, G-protein coupled receptor 40, FFA1R, GPCR40, GPR40, Human FFAR1 full length protein-synthetic nanodisc
Hersteller: DIMA
Hersteller-Nr: FLP100134

Eigenschaften

Anwendung: Full length transmembrane protein, FA, ELISA, screening, immunization, cell-based assays, crystallization
Konjugat: No
Wirt: Human cells
Spezies-Reaktivität: human
MW: 31.5 kD
Format: Lyophilized

Handhabung & Sicherheit

Lagerung: -20°C (avoid repeat freezing and thawing cycles)
Versand: +20°C (International: +20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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