Cynomolgus CD3D and CD3E Heterodimer Protein, His Tag and hFc Tag

Cynomolgus CD3D and CD3E Heterodimer Protein, His Tag and hFc Tag
NEU
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
DIM-PME-C100054.10 10 µg - -

7 - 16 Werktage*

134,00 €
DIM-PME-C100054.50 50 µg - -

7 - 16 Werktage*

469,00 €
DIM-PME-C100054.100 100 µg - -

7 - 16 Werktage*

700,00 €
 
Recombinant Cynomolgus CD3D Protein with C-terminal 10×His tag and Cynomolgus CD3E Protein with... mehr
Produktinformationen "Cynomolgus CD3D and CD3E Heterodimer Protein, His Tag and hFc Tag"
Recombinant Cynomolgus CD3D Protein with C-terminal 10×His tag and Cynomolgus CD3E Protein with C-terminal human Fc tag. CD3D(Phe22-Ala105) 10×His tag and CD3E(Gln22-Asp117) hFc(Glu99-Ala330), Protein function: Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3D plays an essential role in thymocyte differentiation. Indeed, participates in correct intracellular TCR-CD3 complex assembly and surface expression. In absence of a functional TCR-CD3 complex, thymocytes are unable to differentiate properly. Interacts with CD4 and CD8 and thus serves to establish a functional link between the TCR and coreceptors CD4 and CD8, which is needed for activation and positive selection of CD4 or CD8 T-cells. [The UniProt Consortium]
Schlagworte: CD3-DELTA, IMD19, T3D and IMD18, T3E, TCRE
Hersteller: DIMA
Hersteller-Nr: PME-C100054

Eigenschaften

Konjugat: No
Wirt: Human cells
Spezies-Reaktivität: Cynomolgus
MW: 10.9/ kD
Reinheit: >85% (SDS-PAGE)
Format: Lyophilized

Handhabung & Sicherheit

Lagerung: -20°C (avoid repeat freezing and thawing cycles)
Versand: +20°C (International: +20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
Hier folgen Informationen zur Produktreferenz. mehr
Hier kriegen Sie ein Zertifikat
oder , um Analysenzertifikate anzufordern.
Bewertungen lesen, schreiben und diskutieren... mehr
Kundenbewertungen für "Cynomolgus CD3D and CD3E Heterodimer Protein, His Tag and hFc Tag"
Bewertung schreiben
oder , um eine Produktbewertung abzugeben.
Zuletzt angesehen