CD40 (human):Fc (human) (rec.)

The extracellular domain of human CD40 (aa 21-193) is fused to the N-terminus of the Fc region of human IgG1. CD40 protein function: Receptor for TNFSF5/CD40LG. [The UniProt Consortium] CD40 [TNFRSF5] is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins and play an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 contains 4 cysteine-rich repeats in the extracellular domain and is expressed in B cells, dendritic cells, macrophages, endothelial cells and several tumor cell lines. The cognate interaction between CD40 and CD40 ligand (CD154) on T cells activates NF-kappaB, Jun N-terminal kinase and Janus kinase signal transducers and activators of transcription pathways.