Survodutide

Survodutide is a dual peptide agonist of the glucagon-like peptide 1 receptor (GLP-1R) and glucagon receptor (GCGR). It increases cAMP accumulation in CHO-K1 cells expressing GLP-1R or GCGR in reporter assays (EC50s = 0.33 and 0.52 nM, respectively) and potentiates glucose-induced insulin secretion in isolated mouse, rat, and perifused human pancreatic islets. Survodutide (3 and 30 nmol/kg per day) reduces body weight and food intake in diet-induced obese mice, but the reduction in food intake diminishes over time and returns to baseline within approximately 15 days. It reduces the levels of hepatic triglycerides and cholesterol, as well as plasma levels of glucagon, cholesterol, triglycerides, alanine transaminase (ALT), aspartate aminotransferase (AST), insulin, and leptin in the same mice. Survodutide (10 nmol/kg per day) also increases energy expenditure in diet-induced obese mice.Formal Name: L-histidyl-1-aminocyclobutanecarbonyl-L-glutaminylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-alpha-aspartyl-L-tyrosyl-L-seryl-L-lysyl-L-tyrosyl-L-leucyl-L-alpha-aspartyl-L-alpha-glutamyl-L-arginyl-L-alanyl-L-alanyl-L-lysyl-L-alpha-aspartyl-L-phenylalanyl-L-isoleucyl-N6-[N-(17-carboxy-1-oxoheptadecyl)-L-gamma-glutamylglycyl-L-serylglycyl-L-serylglycylglycyl]-L-lysyl-L-tryptophyl-L-leucyl-L-alpha-glutamyl-L-seryl-L-alaninamide. CAS Number: 2805997-46-8. Synonyms: BI-456906. Molecular Formula: C192H289N47O61. Formula Weight: 4231.7. Purity: >98%. Formulation: (Request formulation change), A solid. Peptide Sequence: H-Ac4c-QGTFTSDYSKYLDERAAKDFI-X-WLESA-NH2 where Ac4c = 1-Aminocyclobutane-1-carboxylic Acid and X = A glycine-serine linker carrying a C18 di-acid. Solubility: PBS (pH 7.2): Soluble: >10 mg/ml. SMILES: C[C@@H](C(N)=O)NC([C@H](CO)NC([C@H](CCC(O)=O)NC([C@H](CC(C)C)NC([C@H](CC1=CNC2=C1C=CC=C2)NC([C@H](CCCCNC(CNC(CNC([C@H](CO)NC(CNC([C@H](CO)NC(CNC(CC[C@@H](C(O)=O)NC(CCCCCCCCCCCCCCCCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC([C@H]([C@@H](C)CC)NC([C@H](CC3=CC=CC=C3)NC([C@H](CC(O)=O)NC([C@H](CCCCN)NC([C@H](C)NC([C@H](C)NC([C@H](CCCNC(N)=N)NC([C@H](CCC(O)=O)NC([C@H](CC(O)=O)NC([C@H](CC(C)C)NC([C@H](CC4=CC=C(O)C=C4)NC([C@H](CCCCN)NC([C@H](CO)NC([C@H](CC5=CC=C(O)C=C5)NC([C@H](CC(O)=O)NC([C@H](CO)NC([C@H]([C@H](O)C)NC([C@H](CC6=CC=CC=C6)NC([C@H]([C@H](O)C)NC(CNC([C@H](CCC(N)=O)NC(C7(NC([C@H](CC8=CNC=N8)N)=O)CCC7)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O. InChi Code: InChI=1S/C192H289N47O61/c1-12-103(6)157(186(295)221-122(170(279)227-134(83-113-88-203-119-48-34-33-47-117(113)119)177(286)223-128(77-101(2)3)173(282)219-126(66-70-153(261)262)172(281)232-140(97-242)183(292)210-104(7)160(197)269)51-37-40-75-201-146(252)90-205-147(253)91-206-165(274)138(95-240)215-149(255)93-208-166(275)139(96-241)214-148(254)92-204-144(250)68-64-127(189(298)299)213-145(251)53-31-23-21-19-17-15-13-14-16-18-20-22-24-32-54-151(257)258)237-181(290)132(79-109-43-27-25-28-44-109)226-179(288)136(86-155(265)266)228-168(277)120(49-35-38-73-193)216-162(271)106(9)211-161(270)105(8)212-167(276)123(52-41-76-202-191(198)199)217-171(280)125(65-69-152(259)260)220-178(287)135(85-154(263)264)229-174(283)129(78-102(4)5)222-175(284)130(81-111-55-59-115(247)60-56-111)224-169(278)121(50-36-39-74-194)218-184(293)141(98-243)233-176(285)131(82-112-57-61-116(248)62-58-112)225-180(289)137(87-156(267)268)230-185(294)142(99-244)234-188(297)159(108(11)246)238-182(291)133(80-110-45-29-26-30-46-110)231-187(296)158(107(10)245)236-150(256)94-207-164(273)124(63-67-143(196)249)235-190(300)192(71-42-72-192)239-163(272)118(195)84-114-89-200-100-209-114/h25-30,33-34,43-48,55-62,88-89,100-108,118,120-142,157-159,203,240-248H,12-24,31-32,35-42,49-54,63-87,90-99,193-195H2,1-11H3,(H2,196,249)(H2,197,269)(H,200,209)(H,201,252)(H,204,250)(H,205,253)(H,206,274)(H,207,273)(H,208,275)(H,210,292)(H,211,270)(H,212,276)(H,213,251)(H,214,254)(H,215,255)(H,216,271)(H,217,280)(H,218,293)(H,219,282)(H,220,287)(H,221,295)(H,222,284)(H,223,286)(H,224,278)(H,225,289)(H,226,288)(H,227,279)(H,228,277)(H,229,283)(H,230,294)(H,231,296)(H,232,281)(H,233,285)(H,234,297)(H,235,300)(H,236,256)(H,237,290)(H,238,291)(H,239,272)(H,257,258)(H,259,260)(H,261,262)(H,263,264)(H,265,266)(H,267,268)(H,298,299)(H4,198,199,202)/t103-,104-,105-,106-,107+,108+,118-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,157-,158-,159-/m0/s1. InChi Key: MEDXQFAHWBMVIM-PCLHIQTFSA-N.