S-Acetyl-L-glutathione

S-Acetyl-L-glutathione is a derivative of glutathione (GSH, Cay-10007461). It is more stable in plasma than GSH and, unlike GSH, can be taken up into cells, where it is converted to GSH by intracellular thioesterases. S-Acetyl-L-glutathione (50 µM) increases intracellular GSH levels in primary fibroblasts derived from patients with glutathione synthetase deficiency. It induces apoptosis in Daudi, Raji, and Jurkat lymphoma cells when used at a concentration of 5 mM. It inhibits the replication of herpes simplex virus 1 (HSV-1) in human foreskin fibroblasts when used at concentrations of 5 and 10 mM. S-Acetyl-L-glutathione (6.25 µg/g per day), but not GSH, increases survival in a mouse model of HSV-1 infection.Formal Name: L-gamma-glutamyl-S-acetyl-L-cysteinyl-glycine. CAS Number: 3054-47-5. Synonyms: S-Acetylglutathione. Molecular Formula: C12H19N3O7S. Formula Weight: 349.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (pH 7.2): 1 mg/ml. SMILES: OC([C@@H](N)CCC(N[C@@H](CSC(C)=O)C(NCC(O)=O)=O)=O)=O. InChi Code: InChI=1S/C12H19N3O7S/c1-6(16)23-5-8(11(20)14-4-10(18)19)15-9(17)3-2-7(13)12(21)22/h7-8H,2-5,13H2,1H3,(H,14,20)(H,15,17)(H,18,19)(H,21,22)/t7-,8-/m0/s1. InChi Key: FVRWSIPJNWXCEO-YUMQZZPRSA-N.