Oleoyl proline

Description: Oleoyl proline is an N-acyl amine that can be detected in bovine brain extracts and D. melanogaster larvae using mass spectrometry. In a preclinical model of pain, mice lacking fatty acid amide hydrolase (FAAH KO) had decreased N-oleoyl proline levels in the lumbar spinal cord after capsaicin administration (1 µg/10 µl). Smiles: C(CCCCCCC/C=C\CCCCCCCC)(=O)N1[C@H](C(O)=O)CCC1. References: Hong K, Zhao G, Hong Z, Sun Z, Yang Y, Clifford PS, Davis MJ, Meininger GA, Hill MA. Mechanical activation of angiotensin II type 1 receptors causes actin remodelling and myogenic responsiveness in skeletal muscle arterioles. J Physiol. 2016 Dec 1,594(23):7027-7047. doi: 10.1113/JP272834. Epub 2016 Oct 13. PubMed PMID: 27531064, PubMed Central PMCID: PMC5134373.