Novokinin acetate

Description: Novokinin acetate exhibited an affinity for the AT2 receptor with Ki of 7 nM, and its antihypertensive and vasorelaxing activities were blocked by PD123319, an AT2 receptor antagonist. Target: RAAS. Smiles: CC(C)C[C@@H](C(N[C@@H](CCCCN)C(N(CCC1)[C@@H]1C(N[C@@H](Cc1c[nH]c2c1cccc2)C(O)=O)=O)=O)=O)NC([C@H](CCC1)N1C([C@H](CCCNC(N)=N)N)=O)=O.CC(O)=O. References: Masaaki Yoshikawa, et al. The pharmacological effects of novokinin, a designed peptide agonist of the angiotensin AT2 receptor. Curr Pharm Des. 2013,19(17):3009-12.