Nosiheptide

Nosiheptide is a thiopeptide antibiotic that inhibits bacterial protein synthesis by interfering with the function of elongation factors. It is effective against many different methicillin-resistant S. aureus strains (MICs = 0.25 mg/L), Enterococcus spp (MICs = 0.125 mg/L), and the BI strain of C. difficile (MIC = 0.008 mg/L) but inactive against most Gram-negative bacteria.Formal Name: N-[1-(aminocarbonyl)ethenyl]-2-[(11S,14Z,21S,23S,29S)-14-ethylidene-9,10,11,12,13,14,19,20,21,22,23,24,26,33,35,36-hexadecahydro-3,23-dihydroxy-11-[(1R)-1-hydroxyethyl]-31-methyl-9,12,19,24,33,43-hexaoxo-30,32-imino-8,5:18,15:40,37-trinitrilo-21,36-([2,4]-endothiazolomethanimino)-4-thiazolecarboxamide. CAS Number: 56377-79-8. Synonyms: Multhiomycin, NSC 307240, RP 9671. Molecular Formula: C51H43N13O12S6. Formula Weight: 1222.4. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: Soluble, DMSO: Soluble, Ethanol: Soluble, Methanol: Soluble. lambdamax: 217 nm. SMILES: OC1=C(C2=NC(C(NC(C(N)=O)=C)=O)=CS2)N=C(C3=CSC([C@](NC(C4=CSC([C@](NC(C5=CSC(/C(NC([C@](NC(C6=CSC7=N6)=O)([H])[C@@H](O)C)=O)=C/C)=N5)=O)([H])C[C@H](O)C(OC8)=O)=N4)=O)([H])CSC(C9=C(C)C(C8=CC=C%10)=C%10N9)=O)=N3)C7=C1. InChi Code: InChI=1S/C51H43N13O12S6/c1-5-23-46-60-28(14-79-46)41(70)56-25-10-33(67)50(74)76-11-21-7-6-8-24-34(21)18(2)35(54-24)51(75)82-17-31(57-42(71)29-15-80-47(25)61-29)48-58-26(12-78-48)37-22(45-59-30(13-77-45)43(72)64-36(20(4)65)44(73)55-23)9-32(66)38(63-37. InChi Key: OQAOHXRUMXWDLQ-OIHXUFRMSA-N.