NF-kappaB Control

NF-kappaB inhibitor (Cay-17493) is a synthetic peptide corresponding to the nuclear localization sequence (NLS) of NF-kappaB p105 subunit (also known as p50) appended to a hydrophobic sequence to facilitate import into living cells. It blocks the nuclear import of p105 in cells treated with activators of NF-kappaB signaling, including LPS and TNF-alpha. NF-kappaB control is a peptide that is identical in sequence to NF-kappaB inhibitor, except two essential, basic residues of the p105 NLS are substituted with non-basic amino acids. It is ineffective at blocking the activation of NF-kappaB signaling and is used as a negative control peptide.CAS Number: 201608-17-5. Synonyms: SN50M. Molecular Formula: C123H215N33O30S. Formula Weight: 2668.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 10 mg/ml, Ethanol: 1 mg/ml, PBS (pH 7.2): 1 mg/ml. SMILES: [H]N[C@H](C(N[C@H](C(N[C@@H](C(C)C)C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N1CCC[C@H]1C(N[C@H](C(N[C@@H](C(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@H](C(N2CCC[C@H]2C(N[C@@H](C(C)C)C(N[C@@H](CCC(N)=O). InChi Code: InChI=1S/C123H215N33O30S/c1-59(2)50-80(146-112(175)85(55-64(11)12)149-118(181)96(67(17)18)152-102(165)73(25)135-114(177)88-36-32-47-155(88)121(184)87(56-65(13)14)150-113(176)83(53-62(7)8)144-100(163)71(23)136-116(179)95(66(15)16)151-101(164)72(24)133. InChi Key: NAOYXUUPTUDXHE-YQTWEEOYSA-N.