H-Gly-Pro-Arg-Pro-OH (acetate)

H-Gly-Pro-Arg-Pro-OH (GPRP) is a peptide corresponding partly to the amino terminus of the Aalpha chain and Bbeta chain of fibrin. It inhibits the spontaneous polymerization of fibrin monomers and also inhibits ADP-induced platelet aggregation (IC50 = 3 mM). GPRP binds to the fibrinogen D domain, inhibiting the ability of fibrinogen to bind to the platelet membrane glycoprotein GPIIb/IIIa.Formal Name: glycyl-L-prolyl-L-arginyl-L-proline, monoacetate. CAS Number: 157009-81-9. Synonyms: GPRP. Molecular Formula: C18H31N7O5 . C2H4O2. Formula Weight: 485.5. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (pH 7.2): 10 mg/ml. lambdamax: 208, 279 nm. SMILES: O=C(N1CCC[C@H]1C(O)=O)[C@H](CCCNC(N)=N)NC([C@@H]2CCCN2C(CN)=O)=O.OC(C)=O. InChi Code: InChI=1S/C18H31N7O5.C2H4O2/c19-10-14(26)24-8-2-5-12(24)15(27)23-11(4-1-7-22-18(20)21)16(28)25-9-3-6-13(25)17(29)30,1-2(3)4/h11-13H,1-10,19H2,(H,23,27)(H,29,30)(H4,20,21,22),1H3,(H,3,4)/t11-,12-,13-,/m0./s1. InChi Key: ZYTSTPIIKNCGRE-QKWXXBCPSA-N.