Enalaprilat (hydrate)

Enalaprilat is an active metabolite of the angiotensin-converting enzyme (ACE) inhibitor enalapril (Cay-16041).. Enalaprilat is esterified with ethanol to produce enalapril in order to enable oral activity and subsequently metabolized in vivo to the active form by various esterases. Enalaprilat is reported to inhibit ACE activity with an IC50 value of 5.8 nM in vitro.Formal Name: N-[(1S)-1-carboxy-3-phenylpropyl]-L-alanyl-L-proline, dihydrate. CAS Number: 84680-54-6. Molecular Formula: C18H24N2O5 . 2H2O. Formula Weight: 384.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 30 mg/ml, Ethanol: 2 mg/ml, PBS (pH 7.2): 2 mg/ml. SMILES: OC([C@@H](N[C@@H](C)C(N1CCC[C@H]1C(O)=O)=O)CCC2=CC=CC=C2)=O.O.O. InChi Code: InChI=1S/C18H24N2O5.2H2O/c1-12(16(21)20-11-5-8-15(20)18(24)25)19-14(17(22)23)10-9-13-6-3-2-4-7-13,,/h2-4,6-7,12,14-15,19H,5,8-11H2,1H3,(H,22,23)(H,24,25),2*1H2/t12-,14-,15-,,/m0../s1. InChi Key: MZYVOFLIPYDBGD-MLZQUWKJSA-N.