Calcitonin (eel)

Calcitonin is a 32-amino acid peptide hormone that lowers blood calcium levels and inhibits bone resorption. The amino acid sequence of eel calcitonin varies from salmon (Cay-24410) and human (Cay-24409) calcitonin at 3 and 16 positions, respectively. Calcitonin (eel) binds to calcitonin receptor 2 (CTR2) with higher affinity than human, porcine, or rat calcitonin (Kis = 0.01, 2.95, 0.44, and 5.89 nM, respectively, in radioligand binding assays). It inhibits gastric emptying in conscious dogs more potently than human calcitonin when administered at a dose of 10 µg/kg. Calcitonin (eel) increases the paw withdrawal threshold in a mouse model of carrageenan-induced inflammation when administered at a dose of 0.2 µg/paw.Formal Name: 26-L-aspartic acid-27-L-valine-29-L-alanine-calcitonin (salmon). CAS Number: 57014-02-5. Synonyms: eCT, Elcatonin, H-CSNLSTCVLGKLSQELHKLQTYPRTDVGAGTP-NH2, H-Cys-Ser-Asn-Leu-Ser-Thr-Cys-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asp-Val-Gly-Ala-Gly-Thr-Pro-NH2. Molecular Formula: C146H241N43O47S2. Formula Weight: 3414.9. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Water: 10 mg/ml. SMILES: NC([C@@H]1CCCN1C([C@@]([C@H](O)C)([H])NC(CNC([C@@H](NC(CNC([C@H](C(C)C)NC([C@H](CC(O)=O)NC([C@@]([C@H](O)C)([H])NC([C@H](CCCNC(N)=N)NC([C@@H]2CCCN2C([C@H](CC3=CC=C(O)C=C3)NC([C@@]([C@H](O)C)([H])NC([C@H](CCC(N)=O)NC([C@@H](NC([C@H](CCCCN[H])NC([C@H](CC4=CNC=N4)NC([C@@H](NC([C@H](CCC(O)=O)NC([C@H](CCC(N)=O)NC([C@H](CO)NC([C@@H](NC([C@H](CCCCN[H])NC(CNC([C@@H](NC([C@H](C(C)C)NC([C@H]5NC([C@@]([C@H](O)C)([H])NC([C@H](CO)NC([C@@H](NC([C@H](CC(N)=O)NC([C@H](CO)NC([C@H](CSSC5)N[H])=O)=O)=O)CC(C)C)=O)=O)=O)=O)=O)CC(C)C)=O)=O)=O)CC(C)C)=O)=O)=O)=O)CC(C)C)=O)=O)=O)CC(C)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)=O)=O)=O. InChi Code: InChI=1S/C146H241N43O47S2/c1-66(2)47-88(175-140(231)112(72(13)14)184-137(228)100-64-238-237-63-81(149)119(210)178-97(60-190)135(226)174-94(54-105(152)200)132(223)172-92(51-70(9)10)130(221)180-99(62-192)136(227)187-115(76(18)195)143(234)181-100)120(211)159-58-107(202)163-82(27-20-22-42-147)121(212)169-91(50-69(7)8)129(220)179-98(61-191)134(225)167-85(36-39-103(150)198)123(214)165-87(38-41-109(204)205)124(215)171-90(49-68(5)6)128(219)173-93(53-79-56-156-65-161-79)131(222)164-83(28-21-23-43-148)122(213)170-89(48-67(3)4)127(218)166-86(37-40-104(151)199)126(217)186-114(75(17)194)142(233)177-96(52-78-32-34-80(197)35-33-78)144(235)189-46-26-31-102(189)138(229)168-84(29-24-44-157-146(154)155)125(216)185-113(74(16)193)141(232)176-95(55-110(206)207)133(224)183-111(71(11)12)139(230)160-57-106(201)162-73(15)118(209)158-59-108(203)182-116(77(19)196)145(236)188-45-25-30-101(188)117(153)208/h32-35,56,65-77,81-102,111-116,190-197H,20-31,36-55,57-64,147-149H2,1-19H3,(H2,150,198)(H2,151,199)(H2,152,200)(H2,153,208)(H,156,161)(H,158,209)(H,159,211)(H,160,230)(H,162,201)(H,163,202)(H,164,222)(H,165,214)(H,166,218)(H,167,225)(H,168,229)(H,169,212)(H,170,213)(H,171,215)(H,172,223)(H,173,219)(H,174,226)(H,175,231)(H,176,232)(H,177,233)(H,178,210)(H,179,220)(H,180,221)(H,181,234)(H,182,203)(H,183,224)(H,184,228)(H,185,216)(H,186,217)(H,187,227)(H,204,205)(H,206,207)(H4,154,155,157)/t73-,74+,75+,76+,77+,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,111-,112-,113-,114-,115-,116-/m0/s1. InChi Key: JDJALSWDQPEHEJ-LMVCGNDWSA-N.