Brain Natriuretic Peptide-32 (rat) (acetate)

Brain natriuretic peptide-32 (BNP-32) is a peptide fragment of the cardiovascular hormone precursor proBNP. It binds to natriuretic peptide receptors on rat vascular smooth muscle cells (IC50 = 7.3 nM) and induces cGMP accumulation in the same cells (EC50 = 170 nM). BNP-32 induces relaxation of norepinephrine-precontracted isolated rat aortic strips (EC50 = 6.7 nM). It increases urine and urinary electrolyte excretion and induces hypotension in rats when administered at a dose of 3 µg/kg.Synonyms: B-type Natriuretic Peptide-32, BNP-32, BNP (14-45), Brain Natriuretic Polypeptide-32. Molecular Formula: C146H239N47O44S3 . XC2H4O2. Formula Weight: 3452.9. Purity: >98%. Formulation: (Request formulation change), A solid. Peptide Sequence: NSKMAHSSSCFGQKIDRIGAVSRLGCDGLRLF-OH. Solubility: Water: Soluble. SMILES: O=C(N[C@@H](CO)C(N[C@@H](CCCCN)C(N[C@@H](CCSC)C(N[C@H](C(N[C@@H](CC1=CNC=N1)C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H](CSSC[C@H](N2)C(N[C@@H](CC(O)=O)C(NCC(N[C@H](C(N[C@@H](CCC/N=C(N)/N)C(N[C@H](C(N[C@H](C(O)=O)CC3=CC=CC=C3)=O)CC(C)C)=O)=O)CC(C)C)=O)=O)=O)C(N[C@H](C(NCC(N[C@@H](CCC(N)=O)C(N[C@@H](CCCCN)C(N[C@@](C(N[C@@H](CC(O)=O)C(N[C@@H](CCC/N=C(N)/N)C(N[C@@](C(NCC(N[C@H](C(N[C@@H](C(C)C)C(N[C@@H](CO)C(N[C@@H](CCC/N=C(N)/N)C(N[C@H](C(NCC2=O)=O)CC(C)C)=O)=O)=O)=O)C)=O)=O)([H])[C@@H](C)CC)=O)=O)=O)([H])[C@@H](C)CC)=O)=O)=O)=O)CC4=CC=CC=C4)=O)=O)=O)=O)=O)=O)C)=O)=O)=O)[C@H](CC(N)=O)N[H].CC(O)=O. InChi Code: InChI=1S/C146H239N47O44S3.C2H4O2/c1-16-75(11)114-140(233)165-59-107(201)167-77(13)117(210)191-113(74(9)10)141(234)189-102(67-198)134(227)176-86(38-29-46-160-145(154)155)124(217)179-90(49-71(3)4)119(212)162-62-110(204)171-103(138(231)182-95(56-111(205)206)121(214)164-61-109(203)170-91(50-72(5)6)129(222)173-85(37-28-45-159-144(152)153)125(218)180-92(51-73(7)8)130(223)184-97(143(236)237)53-80-33-22-19-23-34-80)68-239-240-69-104(139(232)181-93(52-79-31-20-18-21-32-79)120(213)163-60-108(202)169-88(40-41-105(150)199)126(219)172-84(36-25-27-44-148)127(220)193-115(76(12)17-2)142(235)183-96(57-112(207)208)132(225)174-87(128(221)192-114)39-30-47-161-146(156)157)190-137(230)101(66-197)188-136(229)100(65-196)187-135(228)99(64-195)186-131(224)94(54-81-58-158-70-166-81)178-116(209)78(14)168-122(215)89(42-48-238-15)177-123(216)83(35-24-26-43-147)175-133(226)98(63-194)185-118(211)82(149)55-106(151)200,1-2(3)4/h18-23,31-34,58,70-78,82-104,113-115,194-198H,16-17,24-30,35-57,59-69,147-149H2,1-15H3,(H2,150,199)(H2,151,200)(H,158,166)(H,162,212)(H,163,213)(H,164,214)(H,165,233)(H,167,201)(H,168,215)(H,169,202)(H,170,203)(H,171,204)(H,172,219)(H,173,222)(H,174,225)(H,175,226)(H,176,227)(H,177,216)(H,178,209)(H,179,217)(H,180,218)(H,181,232)(H,182,231)(H,183,235)(H,184,223)(H,185,211)(H,186,224)(H,187,228)(H,188,229)(H,189,234)(H,190,230)(H,191,210)(H,192,221)(H,193,220)(H,205,206)(H,207,208)(H,236,237)(H4,152,153,159)(H4,154,155,160)(H4,156,157,161),1H3,(H,3,4)/t75-,76-,77-,78-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,113-,114-,115-,/m0./s1. InChi Key: WMDBJLZJMHKFIB-HXFOMJTMSA-N.