alpha-Amanitin

alpha-Amanitin is a cyclic peptide found in several species of the Amanita genus as well as other poisonous fungi. At 1, 10, and 50 µg/ml, respectively, alpha-amanitin inhibits RNA polymerase II, III, and IV, preventing translocation of the enzymes on DNA, which significantly slows the rate of transcription. RNA polymerase I is insensitive to its effects. This toxin is used in molecular biology to distinguish among types of RNA polymerase in a sample and to arrest RNA synthesis in transcription studies.CAS Number: 23109-05-9. Molecular Formula: C39H54N10O14S. Formula Weight: 919.0. Purity: >90%. Formulation: (Request formulation change), A crystalline solid. Solubility: Water: 1mg/ml. lambdamax: 303 nm. SMILES: O=C(N[C@@]1([H])[C@@H](C)[C@@H](O)CO)[C@@]2([H])N(C[C@H](O)C2)C([C@H](CC(N)=O)NC([C@@]([H])(NC(CNC([C@@]([C@H](CC)C)([H])NC(CN3)=O)=O)=O)CS(C4=C(C(C=CC(O)=C5)=C5N4)C[C@@H](C3=O)NC1=O)=O)=O)=O. InChi Code: InChI=1S/C39H54N10O14S/c1-4-16(2)31-36(60)42-11-29(55)43-25-15-64(63)38-21(20-6-5-18(51)7-22(20)46-38)9-23(33(57)41-12-30(56)47-31)44-37(61)32(17(3)27(53)14-50)48-35(59)26-8-19(52)13-49(26)39(62)24(10-28(40)54)45-34(25)58/h5-7,16-17,19,23-27,31-32,46. InChi Key: CIORWBWIBBPXCG-JAXJKTSHSA-N.