SRD5A3 (Vector pUC, Accession No. BC002480)

Length: 957 Sequence: atggctccct gggcggaggc cgagcactcg gcgctgaacc cgctgcgcgc ggtgtggctc acgctgaccg ccgccttcct gctgacccta ctgctgcagc tcctgccgcc cggcctgctc ccgggctgcg cgatcttcca ggacctgatc cgctatggga aaaccaagtg tggggagccg tcgcgccccg ccgcctgccg agcctttgat gtccccaaga gatatttttc ccacttttat atcatctcag tgctgtggaa tggcttcctg ctttggtgcc ttactcaatc tctgttcctg ggagcacctt ttccaagctg gcttcatggt ttgctcagaa ttctcggggc ggcacagttc cagggagggg agctggcact gtctgcattc ttagtgctag tatttctgtg gctgcacagc ttacgaagac tcttcgagtg cctctacgtc agtgtcttct ccaatgtcat gattcacgtc gtgcagtact gttttggact tgtctattat gtccttgttg gcctaactgt gctgagccaa gtgccaatgg atggcaggaa tgcctacata acagggaaaa atctattgat gcaagcacgg tggttccata ttcttgggat gatgatgttc atctggtcat ctgcccatca gtataagtgc catgttattc tcggcaatct caggaaaaat aaagcaggag tggtcattca ctgtaaccac aggatcccat ttggagactg gtttgaatat gtttcttccc ctaactactt agcagagctg atgatctacg tttccatggc cgtcaccttt gggttccaca acttaacttg gtggctagtg gtgacaaatg tcttctttaa tcaggccctg tctgcctttc tcagccacca attctacaaa agcaaatttg tctcttaccc gaagcatagg aaagctttcc taccattttt Protein function: Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N- glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. Also able to convert testosterone (T) into 5- alpha-dihydrotestosterone (DHT). [The UniProt Consortium]