SPTLC2 (Vector pENTR223.1, Accession No. BC005123)

Length: 1689 Sequence: atgcggccgg agcccggagg ctgctgctgc cgccgcacgg tgcgggcgaa tggctgcgtg gcgaacgggg aagtacggaa cgggtacgtg aggagcagcg ctgcagccgc agccgcagcc gccgccggcc agatccatca tgttacacaa aatggaggac tatataaaag accgtttaat gaagcttttg aagaaacacc aatgctggtt gctgtgctca cgtatgtggg gtatggcgta ctcaccctct ttggatatct tcgagatttc ttgaggtatt ggagaattga aaagtgtcac catgcaacag aaagagaaga acaaaaggac tttgtgtcat tgtatcaaga ttttgaaaac ttttatacaa ggaatctgta catgaggata agagacaact ggaatcggcc aatctgtagt gtgcctggag ccagggtgga catcatggag agacagtctc atgattataa ctggtccttc aagtatacag ggaatataat aaagggtgtt ataaacatgg gttcctacaa ctatcttgga tttgcacgga atactggatc atgtcaagaa gcagccgcca aagtccttga ggagtatgga gctggagtgt gcagtactcg gcaggaaatt ggaaacctgg acaagcatga agaactagag gagcttgtag caaggttctt aggagtagaa gctgctatgg cgtatggcat gggatttgca acgaattcaa tgaacattcc tgctcttgtt ggcaaaggtt gcctgattct gagtgatgaa ctgaaccatg catcactggt tctgggagcc agactgtcag gagcaaccat tagaatcttc aaacacaaca atatgcaaag cctagagaag ctattgaaag atgccattgt ttatggtcag cctcggacac gaaggccctg gaagaaaatt ctcatccttg tggaaggaat atatagcatg gagggatcta ttgttcgtct tcctgaagtg attgccctca agaagaaata caaggcatac ttgtatctgg atgaggctca cagcattggc gccctgggcc ccacaggccg gggtgtggtg gagtactttg gcctggatcc cgaggatgtg gatgttatga tgggaacgtt cacaaagagt tttggtgctt ctggaggata tattggaggc aagaaggagc tgatagacta cctgcgaaca cattctcata gtgcagtgta tgccacgtca ttgtcacctc ctgtagtgga gcagatcatc acctccatga agtgcatcat ggggcaggat ggcaccagcc ttggtaaaga gtgtgtacaa cagttagctg aaaacaccag gtatttcagg agacgcctga aagagatggg cttcatcatc tatggaaatg aagactctcc agtagtgcct ttgatgctct acatgcctgc caaaattggc gcctttggac gggagatgct gaagcggaac atcggtgtcg ttgtggttgg atttcctgcc accccaatta ttgagtccag agccaggttt tgcctgtcag cagctcatac caaagaaata cttgatactg ctttaaagga gatagatgaa gttggggacc tattgcagct gaagtattcc cgtcatcggt tggtacctct actggacagg ccctttgacg agacgacgta tgaagaaaca Protein function: Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complex displays a preference for C18-CoA substrate. Plays an important role in de novo sphyngolipid biosynthesis which is crucial for adipogenesis. [The UniProt Consortium]