SGMS2 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 1098 Sequence: atggatatca tagagacagc aaaacttgaa gaacatttgg aaaatcaacc cagtgatcct acgaacactt atgcaagacc cgctgaacct gttgaagaag aaaacaaaaa tggcaatggt aaacccaaga gcttatccag tgggctgcga aaaggcacca aaaagtaccc ggactatatc caaattgcta tgcccactga atcaaggaac aaatttccac tagagtggtg gaaaacgggc attgccttca tatatgcagt tttcaacctc gtcttgacaa ccgtcatgat cacagttgta catgagaggg tccctcccaa ggagcttagc cctccactcc cagacaagtt ttttgattac attgataggg tgaaatgggc attttctgta tcagaaataa atgggattat attagttgga ttatggatca cccagtggct gtttctgaga tacaagtcaa tagtgggacg cagattctgt tttattattg gaactttata cctgtatcgc tgcattacaa tgtatgttac tactctacct gtgcctggaa tgcatttcca gtgtgctcca aagctcaatg gagactctca ggcaaaagtt caacggattc tacgattgat ttctggtggt ggattgtcca taactggatc acatatctta tgtggagact tcctcttcag cggtcacacg gttacgctga cactgactta tttgttcatc aaagaatatt cgcctcgtca cttctggtgg tatcatttaa tctgctggct gctgagtgct gccgggatca tctgcattct tgtagcacac gaacactaca ctatcgatgt gatcattgct tattatatca caacacgact gttttggtgg taccattcaa tggccaatga aaagaacttg aaggtctctt cacagactaa tttcttatct cgagcatggt ggttccccat cttttatttt tttgagaaaa atgtacaagg ctcaattcct tgctgcttct cctggccgct gtcttggcct cctggctgct tcaaatcatc atgcaaaaag tattcacggg ttcagaagat tggtgaagac aatgagaaat Protein function: Sphingomyelin synthase that primarily contributes to sphingomyelin synthesis and homeostasis at the plasma membrane. Catalyzes the reversible transfer of phosphocholine moiety in sphingomyelin biosynthesis: in the forward reaction transfers phosphocholine head group of phosphatidylcholine (PC) on to ceramide (CER) to form ceramide phosphocholine (sphingomyelin, SM) and diacylglycerol (DAG) as by-product, and in the reverse reaction transfers phosphocholine from SM to DAG to form PC and CER. The direction of the reaction appears to depend on the levels of CER and DAG in the plasma membrane (PubMed:14685263, PubMed:17449912, PubMed:17982138, PubMed:18370930). Does not use free phosphorylcholine or CDP-choline as donors (PubMed:14685263). Can also transfer phosphoethanolamine head group of phosphatidylethanolamine (PE) on to ceramide (CER) to form ceramide phosphoethanolamine (CPE) (PubMed:19454763). Regulates receptor-mediated signal transduction via mitogenic DAG and proapoptotic CER, as well as via SM, a structural component of membrane rafts that serve as platforms for signal transduction and protein sorting (PubMed:17449912, PubMed:17982138). To a lesser extent, plays a role in secretory transport via regulation of DAG pool at the Golgi apparatus and its downstream effects on PRKD1 (PubMed:18370930, PubMed:21980337). Required for normal bone matrix mineralization (PubMed:30779713). [The UniProt Consortium]